HIV-1 Capsid Simulations (IMAGE)

University of Texas at Austin, Texas Advanced Computing Center

HIV-1 Capsid Simulations

Caption

The HIV-1 capsid encloses its genetic material, travelling all the way to the nucleus of infected white blood cells before it breaks apart to unleash its deadly genetic cargo. Simulations based on experimental evidence were developed on TACC’s Frontera supercomputer and revealed stress-strain patterns of the capsid just prior to the critical break-up stage, indicating potential vulnerabilities to exploit for drug design. Image shows strain of the HIV-1 capsid, with red and blue colors corresponding to compressive and expansive strain, respectively.

Credit

Yu, et al. DOI:10.1073/pnas.2117781119

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