Model of transforming low cloning efficiency buffalo fetal fibroblasts (BFFs) to high cloning efficiency BFFs (IMAGE)

Science China Press

Model of transforming low cloning efficiency buffalo fetal fibroblasts (BFFs) to high cloning efficiency BFFs

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On the left, the high cloning efficiency buffalo fetal fibroblasts (BFFs) displayed high H3K9 acetylation, low H3K9 methylation companying with low heterochromatin protein 1α (HP1α) expression, and robust glycolysis metabolism. On the right are low cloning efficiency BFFs, which chromatin state and metabolic characteristics are the opposite of the cells with high cloning efficiency. Regulating the metabolic pathway of buffalo fibroblasts with low cloning efficiency to glycolysis, the chromatin state of the cells can be shift to a chromatin state with high cloning efficiency.

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