Figure 1. (IMAGE)

Kanazawa University

Figure 1.

Caption

An integrated approach of HS-AFM and molecular docking to reveal the binding mechanism of Apt-7 to CYP24 (A) The three-dimensional view of the top-ranking docked conformations of CYP24 and Apt-7. The predicted binding sites of Apt-7 are shown by arrow. Aptamer binds to the substrate binding site of CYP24 (binding site-1) and to the ADX binding site of CYP24 (binding site-2). (B) Comparison of the pseudo-HS-AFM graphics of CYP24-Apt-7 using molecular docking generated top-ranked pose of CYP24-Apt-7 complex to the real-time images captured by HS-AFM.

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Kanazawa University

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