ML901 mosquito (IMAGE)
Caption
Caption for figure to accompany “Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy by Stanley C. Xie et al. Science abn0611. Diagrammatic representation of the target of a new antimalarial compound, ML901 (coloured structure), that shows highly specific and potent inhibition of the malaria parasite but is non-toxic to mammalian cells. ML901 finds a particular chink in an enzyme called tyrosine tRNA synthetase (depicted in pink), part of the machinery that the malaria parasite uses to generate the proteins needed to reproduce itself. The parasite rapidly grinds to a halt and can’t cause disease or be transmitted to other people via mosquitoes (purple). Image generated by Leann Tilley and Riley Metcalfe
Credit
Image generated by Leann Tilley and Riley Metcalfe
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