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Crimean-Congo hemorrhagic fever virus causes a catastrophic destruction of Kupffer cells in mice lacking type I interferon signaling, as indicated by a nearly complete loss of the Kupffer cell surface marker CLEC4F. In contrast, this image shows that the CLEC4F-positive Kupffer cells (red) are not lost during infection in mice lacking mitochondrial antiviral signaling protein where type I interferon activity was also blocked by antibody. Additionally, viral protein (green) was only detected in the CLEC4F-positive Kupffer cells (red). Cell nuclei were stained in fluorescent blue. These data demonstrate that Crimean-Congo hemorrhagic fever virus liver injury in MAVS-deficient mice is much more limited compared to infection in non-transgenic wild-type mice.
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Jeffrey M. Smith, USAMRIID
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