Steroid receptor structure (IMAGE)

University of Chicago

Steroid receptor structure

Caption

• Rendering of the X-ray crystal structure of the 700-million-year-old ancestral steroid receptor (blue), bound to DNA, gray. Starting from this protein (and eight of its descendants), the Thornton Lab engineered libraries of mutants containing every possible amino acid state at all 76 sites in the protein (spheres).

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Joe Thornton, UChicago

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