Illustration of the dual-regulation strategy for droplets’ precise control of motion behaviors and its sensing applications. (IMAGE)

Science China Press

Illustration of the dual-regulation strategy for droplets’ precise control of motion behaviors and its sensing applications.

Caption

(A) Illustration of dual-regulation for controllable sliding behavior of RCA droplets (the scale bar was 250 μm). (B-D) RCA droplets with ATP concentration of 30 nM and 300 nM sliding in 0°, 45°, and 90° directions, respectively, displaying tunable detection sensitivity and adjustable dynamic ranges. (E-G) When the sliding direction changes from 0°, 45° to 90°, the dynamic range narrows down and the sensitivity (slope) increases, contributing to distinguishing of droplets with smaller change in target’s concentration. Numbers in red are the upper and lower limits of dynamic ranges. The a and the b present the concentrations of ATP: 30 nM and 300 nM, respectively.

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