Fifth generation polyrotaxane (PRX) carriers can effectively deliver CRISPR-Cas9 ribonucleoproteins (RNPs) (IMAGE) Kumamoto University Caption The PRX carrier can cross the cell membrane, avoid endosomal action, and release Cas9 RNP for entry into the nucleus. Credit Image courtesy: Kumamoto University Usage Restrictions Cannot be used without prior permission License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.