Choroid Plexus Volume Linked to Alzheimer’s Disease (IMAGE)

Radiological Society of North America

Choroid Plexus Volume Linked to Alzheimer’s Disease

Caption

MRI processing steps. For volumetry (left), choroid plexus (CP) volume (red) and cerebral cortex volume (green) are segmented from T1-weighted volumetric images by using an automatic volumetric software (Inbrain) based on the FreeSurfer 6.0 platform (upper row). White matter hyperintensity (WMH) volumes (green) are also segmented from three-dimensional (3D) or two-dimensional (2D) fluid-attenuated inversion-recovery (FLAIR) images by using the same software (lower row). The segmented mask volumes are binary. For permeability and susceptibility mapping (right), permeability values (volume transfer constant [Ktrans] and fractional plasma volume) are obtained from dynamic contrast-enhanced MRI scans by using the Patlak model, and CP permeability values are extracted with use of coregistration of the segmented CP (red) of T1-weighted images to the parametric map using a mutual information-based algorithm (upper row). The color scale bar represents the volume transfer constant (in min21). CP susceptibility measures are generated in an analogous manner. Quantitative susceptibility mapping (QSM) is obtained from multidynamic multiecho images by using QSMnet1 (lower row). The grayscale bar represents susceptibility in parts per million.

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Radiological Society of North America

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