Miscarriage rescue in mice (IMAGE) RIKEN Caption Cartoon rendering of the first experiment. (Left) The normal situation in wildtype mice. (Middle) When egg cells do not contain H3K27 trimethylation, maternal Xist is active and lethal for males. (Right) Additional knockout (KO) of maternal Xist prevents male-skewed prenatal death (miscarriages). Further KO of other genes that failed to imprint rescued the enlarged maternal placenta (not depicted). Credit RIKEN Usage Restrictions credit RIKEN License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.