The molecular mechanism underlying the development of arteriosclerosis (IMAGE)

Nagoya City University

The molecular mechanism underlying the development of arteriosclerosis

Caption

The influx of Ca2+ into vascular smooth muscle cells through Cav1.2 within caveolae due to hypertension activates a pathway leading to inflammation and vascular remodeling. This, in turn, causes arteriosclerosis. The CaMKK2 protein is a potential drug target to prevent this process.

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Yoshiaki Suzuki from NCU, Japan Proceedings of the National Academy of Sciences

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