R-loop Formation During DNA Transcription (IMAGE)

University of Washington School of Medicine/UW Medicine

R-loop Formation During DNA Transcription

Caption

A schematic showing how R-loops, a hybrid of RNA and DNA, can form during DNA transcription when the messenger RNA chain being assembled by the RNA polymerase binds to one of the DNA strands. R-loops effectively block replication.

Credit

Merrikh lab/UW Medicine

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