Subverting a Pathogen's Strategy (IMAGE)

University of Pennsylvania

Subverting a Pathogen's Strategy

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Mice infected with the bacteria Yersinia pseudotuberculosis form granulomas -- structures that confine pathogens. But those with a mutant form of the RIPK1 enzyme, rendering cells unable to undergo a particular form of cell death called apoptosis, do not. Researchers believe this RIPK1-induced apoptosis is a strategy that helps dying cells alert their neighbors that an infection is present.

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University of Pennsylvania

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