Figure 1 (IMAGE)

Osaka University

Figure 1

Caption

PTH binding to PTH receptor (PTH1R) upregulates SLPI expression. SLPI directly acts in osteoblasts to enhance bone formation by controlling gene expression. Additionally, SLPI promotes the adhesion of osteoblasts to neighboring osteoclasts, thereby increasing direct cell-cell contact. This indirect effect leads to activation of osteoblastic bone formation, and inhibition of osteoclastic bone resorption.

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Osaka University

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