APP & apoE in Brain Cells (IMAGE) University of South Florida Caption This microscopic image shows the merging of APP and apoE in brain cells. This co-localization suggests an age-associated increase in apoE-N-terminal APP interaction and thus higher production of the toxic amyloid-β (Aβ) protein characteristic of Alzheimer's disease. Credit © University of South Florida Usage Restrictions Please use image with appropriate caption. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.