Fig.1. Role of Bacterial Metabolites Lactate and Pyruvate in Intestinal Immune Response (IMAGE)

Osaka University

Fig.1. Role of Bacterial Metabolites Lactate and Pyruvate in Intestinal Immune Response

Caption

Gut microbiota such as lactobacillus produce lactate and pyruvate. These metabolites stimulate intestinal macrophages through the receptor GPR31, allowing macrophages to protrude trans-epithelial dendrites and take up pathogenic bacteria efficiently in the intestine. Accordingly, lactate and pyruvate cause enhanced immune responses to pathogenic bacteria and increased resistance to the infection.

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Osaka University

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