Figure 1 (IMAGE)

Japan Science and Technology Agency

Figure 1

Caption

New optogenetic system to reveal neuronal activity of engram and non-engram ensemble by light.

a. Engram cells can be specifically targeted in c-fos-tTA mice. Thy1-G-CaMP7 is useful for Ca2+ imaging of hippocampal CA1 neurons. Sander symbol, indicating neuronal activation state.
b. Image of observation of fluorescence in mouse brain with miniature fluorescent microscope.
c. Representative image of all engram cells and non-engram control cells detected from a single animal.
d. Normalized calcium transients corresponding to neuronal activity for all engram cells (top) and non-engram cells (bottom) during experience of novel episode (displayed over time).

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