The IL-6-Mediated Radioresistance Model (IMAGE)

Kumamoto University

The IL-6-Mediated Radioresistance Model

Caption

Kumamoto University (Japan) researchers revealed that when oral squamous cell carcinoma (OSCC) cells are exposed to X-ray irradiation, interleukin-6 levels increase and activate the Nrf2-antioxidant pathway. This leads to the production of antioxidants, such as Mn-SOD and IL-6, inside the nucleus and higher cancer cell radioresistance.

Adapted by permission from Macmillan Publishers Ltd on behalf of Cancer Research UK: British Journal of Cancer (Y. Matsuoka, et al., "IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma," British Journal of Cancer, vol. 115, no. 10, pp. 1234-1244, 2016.), copyright 2016.

Credit

Dr. Yuichiro Matsuoka & Dr. Hideki Nakayama

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