Tangle and Plaque in Alzheimer's Brain (IMAGE) Washington University School of Medicine Caption Both a tangle (top left) and a plaque (bottom right) can be seen in the brain of a patient with Alzheimer's disease. Credit Nigel Cairns, Washington University School of Medicine Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.