F12 (IMAGE)

Thayer School of Engineering at Dartmouth

F12

Caption

A molecular model of the F12 biotherapy shows the fold of its polypeptide backbone. Residual T cell epitopes are mapped onto the structure and colored from white (no epitopes) to dark red (dense overlapping epitopes). The muted red coloring indicates that T cell epitopes have been broadly silenced in the engineered F12 variant, and this reduced epitope content underlies the molecule's improved safety and efficacy profile.

Credit

Dartmouth Engineering

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