CAAR: Treating Autoimmune Disease Without Harming Normal Immunity (IMAGE)

University of Pennsylvania School of Medicine

CAAR: Treating Autoimmune Disease Without Harming Normal Immunity

Caption

This is a schematic of how a "chimeric autoantibody receptor," or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease called pemphigus vulgaris, a condition in which a patient's own immune cells attack Dsg3, which normally adheres skin cells.

Credit

Christoph T. Ellebrecht, MD, Perelman School of Medicine, University of Pennsylvania

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