JJyoti Nature Communication 2019 Figure (IMAGE)

Children's National Hospital

JJyoti Nature Communication 2019 Figure

Caption

Fibro/adipogenic precursors (FAPs) control the onset and severity of disease in limb-girdle muscular dystrophy type 2 (LGMD2B)

    a. Healthy and/or pre-symptomatic LGMD2B muscle contains resident FAPs.

    b. After myofiber injury, inflammatory cells invade and trigger FAP proliferation.

    c. In symptomatic LGMD2B muscle, there is a gradual accumulation of extracellular AnxA2, which prolongs the pro-inflammatory environment, causing excessive FAP proliferation.

    d. Blocking aberrant signaling due to AnxA2 buildup blocks FAP accumulation and thus preventing adipogenic loss of dysferlinopathic muscle.

Credit

'Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B.' Published online June 3, 2019, in <em>Nature Communications</em>. Marshall W. Hogarth, Aurelia Defour, Christopher Lazarski, Eduard Gallardo, Jordi Diaz Manera, Terence A. Partridge, Kanneboyina Nagaraju and Jyoti K. Jaiswal. <a href=

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