Compound 194 Reduces NaV1.7 Currents (IMAGE)

University of Arizona Health Sciences

Compound 194 Reduces NaV1.7 Currents

Caption

This image shows the structure of compound 194 (yellow sticks) overlaid on an electrophysiology trace showing reduced sodium currents (yellow vs. black lines) from cells that are treated with compound 194. The structure illustrates the predicted interaction of CRMP2 (pink, PDB 2GSE) with the Nav1.7 channel (cyan, PDB 6J8G).

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University of Arizona Health Sciences

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