SAPH-ire Diagram (IMAGE) Georgia Institute of Technology Caption SAPH-ire analyzes existing data repositories of protein modifications and 3-D protein structures to help scientists identify and target research on "hotspots" likely to be important for biological function. Shown is the structural projection of PTM hotspots onto the 3-D structure of a heterotrimeric G protein. Regions of the protein that are modified are color coded to indicate observation frequency. SAPH-ire integrates these and other features to predict which modifications are most likely to impact the function of the protein. Credit Credit: Torres Laboratory Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.