KO ADP model (IMAGE)

University of California - Irvine

KO ADP model

Caption

Induced pluripotent stem cell-derived microglia (iPSC-microglia) deficient in TREM2 and expressing the genetically encoded calcium indicator, Salsa6f. This red-green tandem indicator stably labels the microglial cell in red (tdTomato) and increases its green intensity (GCaMP6f) with rise in cytosolic calcium. The image shows enhanced calcium signaling and process extension in response to purinergic agonist stimulation (ADP).

Credit

School of Medicine / UCI

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