Fish IBD (IMAGE) Duke University Caption Image of a zebrafish in which the entire intestine is highlighted in red and the expression of the TNF molecule is highlighted in green. Duke researchers have discovered that a gene called uhrf1 acts like a kind of molecular handbrake on TNF, keeping it from setting off the series of pro-inflammatory and immune signals that drive inflammatory bowel diseases. Credit Lindsay Marjoram, Duke University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.