Coronavirus N protein (IMAGE)
Caption
The nucleocapsid phosphoprotein (blue) of SARS-CoV-2 (N) (grey) plays critical roles in multiple processes of the SARS-CoV-2 infection cycle, including replication and transcription, and packaging and protecting the genomic RNA (gRNA) (red). The N protein exists as a dimer in solution and interacts with gRNA predominantly through its structured N-terminal domain. N binds RNA multivalently and as more N proteins become available, stabilizing interactions between RNA and proteins occur, resulting in an organized nucleocapsid. Fluorescence imaging of 1-1000 RNA with a Cy3 fluorescent tag demonstrates that RNA-Cy3 with the addition of FL-N, becomes organized and condensed (red puncta background).
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OSU College of Science
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