Tau Uptake Through HSPGs (IMAGE)

American Society for Biochemistry and Molecular Biology

Tau Uptake Through HSPGs

Caption

The figure shows that cellular tau fibril uptake requires 6-O-sulfation and N-sulfation of the HSPG side chains: The cell in the lower half expresses HSPGs with all the sulfate moieties and internalizes tau via macropinocytosis. The cell in the upper half is genetically modified and lacks N-sulfation (red circles) and 6-O-sulfation (yellow circles) and thus, tau fibril uptake is inhibited.

Credit

Sandi Jo Estill-Terpack, Barbara Stopschinsky

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