AID2 enables rapid target degradation in yeast, mammalian cells, and mice (IMAGE)

Research Organization of Information and Systems

AID2 enables rapid target degradation in yeast, mammalian cells, and mice

Caption

A degron-fused protein of interest is recognized for rapid degradation by a TIR1 mutant only in the presence of an auxin analog, which initiates the degradation process. The target protein is typically depleted in less than a few hours after treatment.

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Masato Kanemaki

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