Dynamics of DNA/DNA Double-Stranded Oligonucleotide in Mouse Liver (IMAGE)

Tokyo Medical and Dental University

Dynamics of DNA/DNA Double-Stranded Oligonucleotide in Mouse Liver

Caption

DNA/DNA double-stranded oligonucleotide is a new concept of oligonucleotide consisting of DNA-based antisense oligonucleotide and DNA-based complementary strand. When α-tocopherol is bound to this duplex and administered systemically, it reaches the mouse liver and subsequently the complementary DNA is degraded, and the released parent single-strand antisense oligonucleotide exerts a high target RNA suppression effect.

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Department of Neurology and Neurological Science,TMDU

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