Transcription Factor DNA Binding (IMAGE)

University of California - Berkeley

Transcription Factor DNA Binding

Caption

The transcription factor IID complex locks onto DNA, checks it's in the right place and then recruits other proteins to start transcribing DNA into RNA. New advances in cryo-EM allowed researchers to define five distinct conformations of TFIID as it locks and loads, providing new targets for drug development.

Credit

Eva Nogales lab, UC Berkeley

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