Transcription Factor DNA Binding (IMAGE) University of California - Berkeley Caption The transcription factor IID complex locks onto DNA, checks it's in the right place and then recruits other proteins to start transcribing DNA into RNA. New advances in cryo-EM allowed researchers to define five distinct conformations of TFIID as it locks and loads, providing new targets for drug development. Credit Eva Nogales lab, UC Berkeley Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.