Vasopressin Induces Urinary Uromodulin Secretion by Activating Protein Kinase A (IMAGE)

Tokyo Medical and Dental University

Vasopressin Induces Urinary Uromodulin Secretion by Activating Protein Kinase A

Caption

Desmopressin increased short-term urinary secretion of uromodulin and reduced kidney uromodulin abundance in vivo. In vitro studies revealed that this rapid effect depends on cAMP/PKA signaling pathway, cell polarity and probably apical proteases.

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Department of Nephrology,TMDU

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