Figure (IMAGE) Osaka University Caption Age-dependent increase in expression of Rubicon, a negative regulator of autophagy, is a cause of age-dependent autophagic impairment and contributes to acceleration of aging in animals. Credit Osaka University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.