Magic Spot ppGpp (IMAGE)

Penn State

Magic Spot ppGpp

Caption

In 1969, Cashel and Gallant identified a magic spot (MS) that appeared on a chromatogram (left) made from bacteria that had been starved a key nutrient. This magic spot was later identified as ppGpp and shown to influence the expression of over 500 genes in response to stress. An innovative crystallization technique now has allowed researchers to determine the structure of ppGpp in complex with bacterial RNA polymerase and DksA (upper right).

Credit

Murakami Laboratory, Penn State

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