Schematic Illustration of Preferential Immune Responses (IMAGE)
Caption
Schematic illustration of preferential immune responses during the cancer-activated DOX prodrug nanoparticle (CAP-NPs)-based chemotherapy:
CAP-NPs exhibit selective tumor accumulation via enhanced permeability and retention (EPR) effect and cancer cell-specific activation by overexpressed cancer-associated cathepsin B. Consequently, CAP-NPs selectively initiate enhanced immunogenic cell death (ICD) in cancer cells by inducing cell surface exposure of calreticulin and extracellular secretion of DAMPs, as well as DC maturation and cytotoxic T cell activation in targeted tumor tissues. Concurrently, CAP-NPs significantly reduce the systemic toxicity and inflammatory response in normal organs. Furthermore, cytotoxicity to immune cells is minimized,
leading to increase DCs maturation and T cell activation.
Credit
Korea Institute of Science and Technology(KIST)
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