Structure of the Asterix/Gtsf1 protein (IMAGE)

Cold Spring Harbor Laboratory

Structure of the Asterix/Gtsf1 protein

Caption

This is a structure of the Asterix/Gtsf1 protein. Asterix/Gtsf1 helps immobilize so-called "jumping genes" in germ cells, a type of cell important for sexual reproduction. CSHL Professor & HHMI Investigator Leemor Joshua-Tor and a research investigator in her lab, Jonathan Ipsaro, used two different biophysical techniques, cryo-EM and NMR, to develop their model. In this NMR structure, the purple helix binds to a tRNA, a special class of RNA, which is speculated to escort it to a jumping gene. The blue surface of the protein is positively charged, which helps it bind to negatively charged RNA molecules. The red area on the right is negatively charged.

Credit

Ipsaro/Joshua-Tor lab, CSHL/2021

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