New Mutation-Testing Technology Has Potential to Guide Targeted Lung & Colorectal Cancer Therapies (IMAGE)

Elsevier Health Sciences

New Mutation-Testing Technology Has Potential to Guide Targeted Lung & Colorectal Cancer Therapies

Caption

Assay principles. Unpurified PCR product is added to a microwell containing probe-conjugated microbeads. A wild-type target hybridizes efficiently to both probes, inducing bead aggregation. Hybridization of a mutant target to the discriminating probe is unfavorable; therefore, the beads remain dispersed. An image of each microwell is obtained and processed to generate a saturation value corresponding to the extent of aggregation.

Credit

The Journal of Molecular Diagnostics

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