Urocortin 2 Stimulates Abnormal Heart Growth (IMAGE) Rockefeller University Press Caption A sustained increase in Ucn2 levels and Crhr2 activation causes a mouse heart to grow abnormally large (right), a response that impairs cardiac function and leads to heart failure. Credit Tsuda et al., 2017 Usage Restrictions Reporters may freely use these materials in news coverage with the appropriate credit information. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.