New Candidate Substrates Identified (IMAGE)

University of Massachusetts Amherst

New Candidate Substrates Identified

Caption

Caulobacter crescentus (above) generates radically different cell types upon division. The ClpXP protease (illustrated below) recognizes and destroys many protein substrates that allow Caulobacter to differentiate into these different cell types. New work identifying scores of new candidate substrates of ClpXP to reveal how protein degradation is critical to cell cycle progression and bacterial development could lead to new antibiotic targets.

Credit

Peter Chien, UMass Amherst

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