KCNQ1 Docking (IMAGE)

University of California - Irvine

KCNQ1 Docking

Caption

UCI researchers reveal how two components of the Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many human organs, including the heart, kidneys, gastrointestinal tract, thyroid and pancreas. This computer model illustrates the novel herbal component, CPT1, an isovaleric acid molecule (green), occupying a novel binding site (R243, red) to activate KCNQ1.

Credit

UCI School of Medicine/Geoff Abbott

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