Sliced View of the cGMP B-site of PKG-1α (IMAGE)

University of Vermont

Sliced View of the cGMP B-site of PKG-1α

Caption

Pictured above is a crystal structure of a sliced view of the cGMP B-site of PKG-Iα at the site of S-tide interaction (green). The deep binding pocket is comprised of mostly hydrophobic amino acid residues. Hydrophilic amino acid residues are predominantly confined to the surface of the protein as depicted by their electrostatic representations (blue-positive, red-negative).

Credit

Wolfgang Dostmann, University of Vermont College of Medicine

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