Foxa Factors Control Liver Cancer Risk (IMAGE) University of Pennsylvania School of Medicine Caption When mice are exposed to a liver carcinogen, normally male mice develop many tumors, while female mice are protected (left part of the figure). However, in mice lacking the Foxa genes, the situation is reversed (right part of the figure). Thus, the Foxa genes are essential determinants of the sexual dimorphism in liver cancer risk. Credit Klaus Kaestner, PhD, Perelman School of Medicine, University of Pennsylvania; Cell Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.