Autoregulation of Osteocyte Sema3A in Bone Homeostasis (IMAGE)

_Tokyo Medical and Dental University

Autoregulation of Osteocyte Sema3A in Bone Homeostasis

Caption

Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote survival, resulting in reduced osteoclastic bone resorption and enhanced osteoblastic bone formation. Sema3A-activated sGC-cGMP signaling through Nrp1 protected osteocytes from apoptosis.

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Department of Cell Signaling,TMDU

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