Making Cancer Go Down in Flames (IMAGE)

Boston Children's Hospital

Making Cancer Go Down in Flames

Caption

At left, cancer cells from an immunologically 'cold' tumor, in which gasdermin E has been suppressed, undergo a slow, uneventful death. Their outer membrane remains intact and they quietly shrink. The cancer cells at right have had gasdermin E re-introduced: they blow up, forming giant membrane balloons, and release molecules that trigger inflammation and a protective immune response.

Credit

Zhibin Zhang/Lieberman Lab, Boston Children's Hospital

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