Mechanism of the HIV entry to cells and its block by a CD4 mimic bearing PEG and a neutralizing antibody. (IMAGE)

Tokyo Medical and Dental University

Mechanism of the HIV entry to cells and its block by a CD4 mimic bearing PEG and a neutralizing antibody.

Caption

The V3 loop of an HIV envelope protein gp120 is exposed by the conformational change of 2). A CD4 mimic with PEG blocks the progress from 1) to 2) (the first arrow), and a neutralizing antibody blocks the progress from 2) to 3) (the second arrow). Without these drugs, HIV enters cells.

Credit

Department of Medicinal Chemistry, TMDU

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