Regional Myocardial Blood Flow Response to Hypercapnia and Adenosine in the Presence of Coronary Stenosis (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Regional Myocardial Blood Flow Response to Hypercapnia and Adenosine in the Presence of Coronary Stenosis

Caption

Panel A shows representative short and long-axis PET images of peak myocardial uptake of 13N-ammonia during hypercapnia of PaCO2 ~ 60 mmHg (CO2), standard clinical dose of adenosine (Adenosine) and at rest with PaCO2 ~ 35 mmHg (Rest) in a canine with a LAD stenosis. Note the lower uptake of the radiotracer in the anterior lateral wall (lower signal in distal LAD segments, yellow arrows) under hypercapnia and adenosine. For the case in panel A, rest and stress MBF (under hypercapnia and adenosine) and corresponding MPR are shown as polar maps in panel B. These images show marked reduction in MBF and MPR in the LAD territory, which are visually evident and spatially concordant under hypercapnia and adenosine.

Credit

Rohan Dharmakumar. Cedars-Sinai Medical Center

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