Cancer Cell Movement (IMAGE)

Cold Spring Harbor Laboratory

Cancer Cell Movement

Caption

Certain regulatory RNAs are involved in cancer cell movement and metastases. On the right, cancer cells are on the move with long, stiff actin filaments (in green) acting like fingers to help it move. Paxillin (red) collects in patches on the cell's edge, sticking it to a surface. On the left, cells lacking one such regulatory RNA, MaTAR25, are flat. Actin filaments and paxillin are disrupted (speckles instead of filaments or patches), so cells are unable to move efficiently, reducing their ability to escape a tumor and metastasize.

Credit

Kung-Chi Chang/Spector lab, 2020

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