Phase Changing Protein FUS (IMAGE)
Caption
The protein FUS, from FUsed in Sarcoma, changes phase. In healthy cells, FUS can switch between floating diffusely in solution (modeled in a test tube, left) and forming condensed droplets (middle). The 'solid' or aggregate phase of FUS (right) has been found in some people with amyotrophic lateral sclerosis (ALS) and a type of dementia. A team of researchers led by Brown University associate professor Nicolas Fawzi identified the molecular interactions that stabilize the condensed phase of the neurodegeneration-associated protein.
Credit
Image: Courtesy Sapun Parekh's lab/University of Texas at Austin
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