The Different Types of Pain Transmission and the Role of REV-ERBs (IMAGE)

Hiroshima University

The Different Types of Pain Transmission and the Role of REV-ERBs

Caption

Normal pain transmission triggers signaling modules to cause a sensation of pain. In chronic pain, activated astrocytes cause an increase in production of these signaling molecules, which leads to more intense or longer-lasting pain. The main finding of the study shows that simulating REV-ERBs in spinal cord astrocytes with an agonist leads to pain relief.

Credit

Professor Morioka, Hiroshima University

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