Schematic representation of the activity of the dendritic cell immunoreceptor during inflammation (IMAGE)

Tokyo University of Science

Schematic representation of the activity of the dendritic cell immunoreceptor during inflammation

Caption

Neuraminidase suppresses autoimmune arthritis and encephalomyelitis by inhibiting dendritic cell and osteoclast activity through removal of sialic acid, thereby exposing asialo-biantennary N-glycan (NA2) and generating inhibitory signals through dendritic cell immunoreceptor (DCIR).

Credit

Yoichiro Iwakura from Tokyo University of Science

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